Significant differences between the в†‘LFTs-group and the normal-LFTs-group were found for age (P=0.01), HRT duration (P=0.004), Tot-Chol (P=0.009) and LDL-Chol (P=0.011). The most frequently abnormality was a raised GGT in 91% of cases в†‘ALT and ALP were found in 40%. Liver enzymes were elevated in 35 (34%) patients, with a duration of 7y (в–.2SD) and age at the first finding of в†‘LFTs 34y (в‘2.9SD). Ascending aorta diameters, measured with echocardiography and cardiac MR, were analyzed. LFTs were collected, along with karyoptype, anthropometric, metabolic and TS-related diseases and treatments. Methods: We reviewed our adult TS cohort. The aim of this study was to analyse the association between в†‘LFTs and a comprehensive panel of TS-related conditions, focusing on metabolic and cardiovascular diseases in order to further elucidate the pathophysiological mechanisms underlying this. The cause and clinical significance are unclear. It suggests that в†‘LFTs may be commoner in TS patients with 45,X0, and/or hypertension, hyperlipidaemia and autoimmunity.ДЄims: Elevated liver function tests (в†‘LFTs) are frequent in TurnerВ’s Syndrome (TS). Liver biopsy was performed in three patients: one normal, one NAFLD and one showed chronic hepatitis.Д¬onclusions: This study confirms that the prevalence of в†‘LFTs increases with age, that an adequate oestrogen milieu may be protective, and HRT does not need to be discontinued in the presence of в†‘LFTs. Two patients had a normal Fibroscan and one a normal MRCP. The frequency of hypertension, dyslipidaemia and thyroid autoimmunity was higher in the в†‘LFTs-group (35% vs 14%, 23% vs 7% and 27% vs 17%, respectively).ДЄbdominal-ultrasonography was normal in ten cases, suggestive of NAFLD (non-alcoholic-fatty-liver-disease) in four and in one showed nodularity and hepatosplenomegaly. 48% of patients with в†‘LFTs had a karyotype 45,X0 vs 32.5% in the normal-LFs-group. Age was significantly higher in the в†‘LFTs-group (42.5 yearв‘3.1 S.D. The prevalence of spontaneous menstruation was higher in the normal-LFTs-group. There was no association between в†‘LFTs and anthropometric values (height/weight/BMI), diabetes, HbA1c, renal or cardiac malformations, and either GH or oestrogen therapy.

In the normal-LFTs-group no past history of в†‘LFTs was noted. Hepatitis serology and autoimmune-markers were negative, bilirubin was normal and no reported alcohol consumption in all.

Results: Twenty six women (38%) had one or more liver enzymes persistently raised (duration 5.6 yearsв“.8 S.D.), with the most frequently elevated enzyme being GGT in 92% of cases, and ALT, ALP and AST in 77, 69 and 38%, respectively. Objectives: To study the prevalence of в†‘LFTs and their relationship with karyotype, anthropometric, metabolic and TS-related conditions: 68 TS women, average age 39 years (range 18в‰¦1 years), were reviewed. Their pathogenesis and clinical significance is unclear. Introduction: Elevated liver function tests (в†‘LFTs) are frequent in TurnerВ’s syndrome (TS), with a prevalence between 20 and 80%, and increases with age.

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